Moreover we found Anti-dsDNA+ patients are more likely to have nephritis symptom, perhaps because signaling of the C3a anaphylatoxin through its G protein-coupled receptor(C3aR), contribute to lupus nephritis15.Consistent with our observed correlation between C3a levels and SLE patient disease activity, prior studies have reported increases in complement split products and disease severity, although the specific association between such activity and C3a has not been reported owing to the very short half-life exhibited by C3a in serum16. The gene discussed is C3; the disease is systemic lupus erythematosus.