CHD4 and hepatocellular carcinoma: Taken together, these data show that when MBD3 is highly expressed in HCC, it can recruit CHD4 and HDAC1 to form NuRD complex and bind to the promoter of tumour suppressor TFPI2, and then inhibit gene transcription by histone deacetylation, so as to promote the proliferation, angiogenesis and metastasis of HCC (Fig. 7).