However, a large body of data suggest that POH1 might act as a positive regulator of AP-1-regulated genes leading to a drug resistance phenotype [3, 27, 67, 69, 75] and recent work suggests that it could also be involved in the regulation of transcriptional programmes associated with cancer stemness [30] and EMT [29, 63, 64]. Here, PSMD14 is linked to cancer.