Similarly, overexpression of POH1 in tumour tissue compared to adjacent normal tissue was demonstrated in oesophageal cancer, hepatocellular carcinoma, colorectal cancer and lung adenocarcinoma, with a worse prognosis in terms of overall survival for tumours with high POH1 versus low POH1 [84, 85, 88]. Here, PSMD14 is linked to colorectal cancer.