We observed that the tumor growth was significantly reduced in mice receiving Mxi1-overexpressing lung cancer cells relative to oe-NC, while opposite effects were observed in mice injected with HCC827 cells expressing oe-Mxi1 + miR-300 mimic or oe-Mxi1 + sh-KLF9 relative to that of oe-Mxi1 + miR-NC or oe-Mxi1 + sh-NC, respectively (Fig. S4A). The gene discussed is KLF9; the disease is neoplasm.