To directly investigate if the SOXE-module is associated with NCSC phenotypic mimicry, as has been reported for Sox10 in mouse mammary tumour cells24, we performed expression and enrichment analyses using two independent genesets: (1) 308 genes represented in at least two of the 78 terms matching ‘neural crest’ in the gene ontology database (‘NC terms’); and (2) transcripts specific to migratory, Sox10+ NCSCs in chick embryos (‘ch.NCSC’; n = 200 genes)55, representing Sox10’s most primitive transcription programme (Supplementary Table 11). The gene discussed is SOX10; the disease is breast cancer.