Conversely, knockout of PTEN-induced kinase 1 (PINK1), parkin RBR E3 ubiquitin protein ligase (PARK2), or BCL2-interacting protein 3 (BNIP3) inhibited mitophagy in TECs, which aggravated kidney injury [45–48]. This evidence concerns the gene BNIP3 and urogenital neoplasm.