C2 and prion disease: The top three pathways in order of significance were, Reactome: Creation of C4 and C2 activators, Classical antibody-mediated complement activation and Fc \documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$$\gamma$$\end{document}γ Receptor (FCGR) activation; STRING: Cholesterol metabolism, Complement and coagulation cascades and prion disease.