SRSF3 and colorectal carcinoma: In the current study, we also confirmed that SRSF3 knockdown attenuated the mRNA level of p53α and elevated the mRNA level of p53β in HCT-116 and SW480 cells, although the TCGA data showed that there was no significant correlation between P53 and SRSF3 expression in CRC clinical samples (Supplementary Fig. 1 F and 2H).