It has also been reported that SRSF3 regulates cell cycle arrest and apoptosis and promotes CRC cell growth by regulating the expression of ArhGAP30 [12], PKM2 [16], MAP4K4 [17], HIPK2 [18], etc. Moreover, our previous study showed that SRSF3 was involved in the splicing of B7-H3 and enhances tumor immune evasion in CRC cells [10]. Here, PKM is linked to colorectal carcinoma.