VCP and frontotemporal dementia: VCP mutations cause inclusion body myopathy with early-onset Paget disease and frontotemporal dementia (IBMPFD), also known as multisystem proteinopathies (MSPs), familial forms of amyotrophic lateral sclerosis (fALS) and/or frontotemporal dementia (FTD) and Parkinson’s disease (PD) [20–23].