Here, YAP1 emerged as a key TF in CF-related EMT, by showing, not only that it is up-regulated in CF versus non-CF cells, but also that YAP1 specifically interacts with F508del-CFTR impairing its traffic, whereas its KD released F508del-CFTR to the PM and rescued its processing and function. The gene discussed is TF; the disease is cystic fibrosis.