However, given that C/EBPβ, TWIST1, TEAD4, and YAP1 all showed differential protein expression in polarized wt- versus F508del-CFTR expressing cells (Fig 2E and F) we considered these data significant enough to suggest an implication of these genes in EMT in the context of CF. The gene discussed is CEBPB; the disease is cystic fibrosis.