CFTR and cystic fibrosis: To further confirm this, we assessed YAP1 expression in different airway cell models (16HBE and 16HBEge cells) expressing wt-, F508del-, and N1303K-CFTR (an additional CF-causing mutation) and observed that also on these cells, with the presence of dysfunctional CFTR, YAP1 expression levels are significantly increased, regardless of the CFTR mutation (Fig S3A and B).