Namely, proteins were selected if they were (i) F508del-CFTR-specific YAP1 interactors defining the biological categories and enriched gene sets related to CF and/or EMT, namely, cell cycle, ECM, inflammation (see Supplemental Data 3), MYC signaling, EMT, mitosis, hypoxia, and TGFβ signaling (see Supplemental Data 4); or (ii) F508del-CFTR–specific YAP1 interactors that are oncogenes or define oncogenic signatures (see Supplemental Data 5). The gene discussed is YAP1; the disease is cystic fibrosis.