SNCA and multiple system atrophy: Synucleinopathies such as Parkinson ́s disease (PD), Dementia with Lewy Bodies (DLB) or Multiple System Atrophy (MSA) are neurodenegerative disease characterised by aggregation of the protein α-synuclein in neurons and/or in oligodendrocytes (glial cytoplasmic inclusions), neuronal loss, and astrogliosis.