The circRNA–miRNA–mRNA triple network was wildly applied in research, Chen X et al. found that CircRNA_28313/miR-195a/CSF1 could regulate osteoclastic differentiation in OVX–induced bone absorption in mice [39], and Shen WX et al. revealed that CircFOXP1/miR-33a-5p/FOXP1 could promote osteogenic differentiation and CircFOXP1 can be used as a potential osteoporosis therapeutic target [40]. The gene discussed is CSF1; the disease is osteoporosis.