Although recent studies have suggested that IL10 have deleterious effect on insulin pathways and weight gain during experimental obesity [84,85], when it comes to the context of helminth infection and high fat diet, increased secretion of IL10 is known to control the development of type 2 diabetes [38], improve triglycerides levels [36], and increase sensitivity to insulin [41]. Here, INS is linked to obesity due to melanocortin 4 receptor deficiency.