BRCA1 and breast cancer: Given the presumption that early age at screening is of a greater benefit than later age at screening for women at high risk, the decision to screen thus becomes an informed clinical decision (after discussion) for women 40 to 49 years of age who possess certain characteristics, such as BRCA1/2 gene variants, family history of breast cancer, or chest radiation at younger than 30 years of age.20 Specifying the concept that a high-risk population needs a different age and frequency of screening recommendations may reduce heterogeneity in plans.