BRCA1 and breast carcinoma: The current USPSTF recommendation defines “high-risk” status as women with a family history of breast cancer or BRCA1/2 (OMIM 113705 and 600185) gene variants or chest radiation at younger than 30 years of age.6 Thus far, however, there is no 1 tool12 to determine high-risk status that may have a different benefit to harm ratio and that may lead to a more frequent number of examinations and narrower age range.