Recently, low DLG2 expression in osteosarcoma (Shao et al. 2019), ovarian cancer (Zhuang et al. 2019) and neuroblastoma (Keane et al. 2020, 2021; Siaw et al. 2020) has been identified as contributing to disease etiology, with low DLG2 expression in neuroblastoma showing increased cell proliferation and poor survival (Keane et al. 2020). The gene discussed is DLG2; the disease is neuroblastoma.