To confirm these results, we determined proliferation in the colon cancer cells SW480 after DLG2 silencing or overexpression, DLG2 silencing resulted in an increase in SW480 proliferation (29.4% more cells, p < 0.001; Fig. 6c) and overexpression resulted in a decrease in proliferation (19.6% less cells, p < 0.001; Fig. 6c) compared to the control, 48 h after transfection. Here, DLG2 is linked to malignant colon neoplasm.