Urolithin-A, Celastrol, Nobiletin, Tacrolimu, Hesperidin, Elabela, Troxerutin, Kaempferide, Leonurine, Ginsenoside Rg1, Melatonin, Araloside-C and Anthocyanin are examples of substances that protect against MI-induced I/R injury or heart failure through modulation of PI3K/AKT pathway. This evidence concerns the gene AKT1 and heart failure.