EGF and neoplasm: And EGFR protein level and its half-life can be extended or decreased by FBXW2 depletion or overexpression, respectively, but FBXW2 dominant-negative mutant has no effect on it; (4) FBXW2 binds to EGFR via its consensus degron motif (TSNNST), and promotes EGFR ubiquitylation and degradation; (5) The tumor growth- and invasion- inhibiting effect of FBXW2 in PCa is casually mediated by down-regulating EGFR and its downstream targets; (6) FBXW2 blocks EGF-induced biological effects.