CD4 and infection: Studies in CD8+ T cells showed that the profile of H3K27me3 (associated with gene repression) and H3K4me3 (associated with gene expression in T cells) correlates in naive CD4+ T cells and TSCM cells and it is segregated from TCM and TEM cells, suggesting that the epigenetic profile of TSCM cells is more similar to naive rather than memory cells, thus explaining their correlation in latency rates versus productive infection rates (98).