Since our results verified that KBTBD7 influences EGFR/PI3K/AKT signaling by regulating PTEN ubiquitin‐dependent degradation, we hypothesize that KBTBD7 may also be related to the EGFR‐TKI treatment response and could be a potential therapeutic target for NSCLC. Here, EGFR is linked to non-small cell lung carcinoma.