AKT3 and breast cancer: To investigate the effect of AKT3 and PI3K/AKT signaling on docetaxel sensitivity in BC cells, we downregulated the expression of AKT3 with a specific siRNA for AKT3 and inhibited the PI3K/AKT signaling using the P-AKT inhibitor, Palomid 529 (P529) (Figure 5a).