GPT and insomnia measurement: In the 1200 mg arm, 1 subject experienced insomnia, and 1 subject experienced asymptomatic elevation in aspartate aminotransferase (AST) and alanine aminotransferase (ALT), with other liver function tests normal (Supplemental Table 1; supplemental material available online with this article; https://doi.org/10.1172/JCI157983DS1).