Although SUMOylation of STAT1 limits its phosphorylation and the cellular responsiveness to IFN-γ (40), SUMOi substantially amplified IFN-γ–induced MHC-I induction in DLBCL cell lines (Figure 5, A and B) without affecting the surface expression of the IFN-γ receptor, IFN-γRα (Supplemental Figure 6A). This evidence concerns the gene IFNG and diffuse large B-cell lymphoma.