EPO and neoplasm: Analysis of mRNA expression in tumor tissue by RT-qPCR revealed that 32-134D treatment significantly decreased the expression of multiple mRNAs encoding angiogenic factors (ANGPTL4, EPO, PGF, and VEGFA) (P < 0.05; Figure 6A) and proteins mediating immunosuppression (B7H4/VTCN1, CD47, CD73, PDL1, SLC2A1/GLUT1, HAVCR2/TIM3, CD70, LDHA, ENTPD1/CD39, and CA9) (P < 0.05; Figure 6B and Supplemental Table 4), whereas 32-134D treatment increased the expression of CXCL9, CXCL10, and IFN-γ (P < 0.05; Figure 6C), which are critical for recruitment and activation of CD8+ T cells and NK cells.