CD70 and neoplasm: In contrast, decreased CD47, CD70, IL-6, and IL-10 mRNA levels were observed in tumor tissue from 32-134D–treated mice (Figure 6, B and D, and Figure 7) but not in cultured Hepa1-6 cells exposed to 32-134D (Figure 3, B and C), which suggests that 32-134D inhibited the expression of these latter mRNAs in immune or other stromal cell types, where HIFs are known to play critical roles (56–61), rather than in tumor cells.