In contrast, decreased CD47, CD70, IL-6, and IL-10 mRNA levels were observed in tumor tissue from 32-134D–treated mice (Figure 6, B and D, and Figure 7) but not in cultured Hepa1-6 cells exposed to 32-134D (Figure 3, B and C), which suggests that 32-134D inhibited the expression of these latter mRNAs in immune or other stromal cell types, where HIFs are known to play critical roles (56–61), rather than in tumor cells. This evidence concerns the gene CD47 and neoplasm.