By contrast, 32-134D treatment led to a decreased percentage of intratumoral CD11b+F4/80+ tumor-associated macrophages (TAMs) and CD11b+Ly6C+ monocytic myeloid-derived suppressor cells (M-MDSCs) (P < 0.05; Figure 5, D and E), which are 2 immune cell populations that are critical mediators of immunosuppression in HCC (55). The gene discussed is ITGAM; the disease is neoplasm.