VEGFC and myocardial ischemia: In this issue of the JCI, Glinton et al. (12) hypothesized that efferocytosis triggers myeloid VEGFC production, which, in turn, promotes the lymphangiogenic response in cardiac repair, thus positioning myeloid-derived VEGFC in the midst of the complex interplay between the inflammatory and lymphangiogenic responses to myocardial ischemia (refs. 4, 13 and Figure 1).