Downregulation of immune-related factors including Ccl20, CSF1, PDGFB and VEGFA by miR-204, in addition to the alteration of immune cells composition such as decreased myeloid-derived suppressor cell (MDSCs) and increased regulatory T cells population by miR-204 could limit metastatic potential of tumor cells therefore, miR-204 exerted immunomodulatory function in BC TME [109]. This evidence concerns the gene VEGFA and breast cancer.