Bioluminescent monitoring of murine transgenic BC model harboring luciferase underlying VEGFR2 promoter revealed that tumor angiogenesis and growth could be attenuated following by intratumoral injection of anti-miR-21 which is associated to HIF-1α/VEGF/VEGFR2 signaling inactivation [148]. The gene discussed is VEGFA; the disease is breast cancer.