In all three minority populations, NUDT15 c.415C > T was the most common variant type, followed by c.55_56insGAGTCG and c.52G > A. Our results showed that 29.9% (n = 202) of Han children with ALL carried the NUDT15 gene with one or more variants. This evidence concerns the gene NUDT15 and acute lymphoblastic leukemia.