We described the results of NUDT15 gene polymorphism in Han Chinese children with ALL, showing the minor allele frequencies (MAFs) of 6.4%, 1.4%, and 13.2% for the NUDT15 c.55_56insGAGTCG, c.52G > A and c.415C > T variants, respectively. Here, NUDT15 is linked to acute lymphoblastic leukemia.