The goals are for (1) early phenotypic recognition leading to genomic diagnosis; (2) appropriate surveillance for progression to CKD, malignancy, and sexual health in patients with WT1 mutations; (3) genetic analysis to precede kidney biopsy in children with SRNS; (4) establish early medical management to modulate proteinuria and preserve long-term kidney function; (5) genetic counseling for the patient and family related to fertility and future pregnancies; and (6) expansion of the knowledge database by collaboration and reporting of new cases. Here, WT1 is linked to chronic kidney disease.