SERPINA1 and hyperinsulinemic hypoglycemia, familial, 4: Family history provides key clues to the presence of genetic pulmonary diseases, such as cystic fibrosis, alpha 1-antitrypsin deficiency, hereditary haemorrhagic telangiectasia, immotile cilia syndrome, situs inversus, spontaneous pneumothorax, atopy, asthma, and immunodeficiency syndromes (66).