We noted that SMYD2, ESM1, ULBP2, NMB, and GAPDHP1 were upregulated in BLCA samples, and C1QTNF7, ATP1A2, FXYD1, CFD, LGI4, ACTA2-AS1, PER1, THSD4, and CILP were downregulated in BLCA samples both in the TCGA-BLCA and GSE133624 datasets. The gene discussed is ACTA2; the disease is bladder transitional cell carcinoma.