However, there is a difficulty in recommending a training intervention for patients with DM that is much superior in terms of effectiveness when it comes to improvement in mitochondrial function, oxidative stress and myopathy, although, still, the literature supports the prescription of combined exercises (aerobic of moderate intensity with resistance training) in view of the benefits achieved in glycemic control and insulin sensitivity, which end up presenting positive results in these deficits (42–44). This evidence concerns the gene INS and myopathy.