Contrastingly, during anaerobic exercise, an increase in catecholamines and a failure in circulating levels of insulin at the end of vigorous exercise in individuals with T1DM increases glucose production by the liver while limiting glucose elimination from skeletal muscle, as well, due to this imbalance in glucose production and utilization, circulating glucose levels increase and hyperglycemia may occur (16, 17). This evidence concerns the gene INS and type 1 diabetes mellitus.