Group 2 was further categorized into Group 2a (mean age 49.27 ± 11.46 years, BMI 26.46 ± 3.69 kg/m2), which included 94 men with hypogonadotropic hypogonadism (low testosterone+low or normal LH) and Group 2b (mean age 60.32 ± 10.56 years, BMI 25.42 ± 2.38 kg/m2), which included 19 men with hypergonadotropic hypogonadism (low testosterone+high LH) (Table 1). The gene discussed is PLOD1; the disease is Hypergonadotropic hypogonadism.