Exposure to the hyperglycemia range (>250 mg/dl) in the HCL group, was reduced by 6.2%, compared to the SAP group, and 3.1%, compared to the PLGS group, while the reduction was not significant between SAP and PLGS groups, confirming the effectiveness of basal insulin modulation in preventing values above the target range. This evidence concerns the gene INS and Hyperglycemia.