PCSK9 and diabetes mellitus: Furthermore, the upward trend remained even after adjustment of age, gestational age, BMI, blood pressure, abdominal girth, family history of diabetes mellitus, TG, LDL-C, and HOMA-IR (model 2, model 3, model 4) compared with those in the first quartile of PCSK9 (all P < 0.05 for a linear trend).