REG3A and Hyperglycemia: However, in addition to being related to pancreatic islet growth, regeneration and the acinar cell type, members of the third subclass of the Reg family, have been observed to be associated with host defenses and hyperglycemia and it has been suggested that bacteria, injury, interleukins (51) or hyperglycemic conditions (52) can regulate or inhibit the expression of REG3A, further complicating the picture for the possible underlying cause for the observed gene expression.