Recently, an analysis of in vivo metastases and clinical data from PCa patients supports that the PGC-1α (transcriptional co-activator peroxisome proliferator-activated receptor gamma coactivator 1-alpha)/c-MYC/ODC1 axis regulates polyamine biosynthesis and PCa aggressiveness (30). The gene discussed is ODC1; the disease is posterior cortical atrophy.