Compared to the traditional cisplatin reacting with DNA in the nucleus and leading to cell death through apoptosis, most Ir(iii)-based cancer agents, as previously reported, also underwent the apoptosis death path;25 whereas cyclometalated Ir2 could localize and accumulate in the lysosomal organelle of A549 cancer cells and induce partial necrosis and autophagic cell death, which is distinct from the apoptosis induced by LA itself. This evidence concerns the gene INSR and cancer.