An increasing number of studies have confirmed that lncRNAs can act as miRNA sponges and thus reduce their regulatory effects on the target mRNAs; for instance, KCNQ1OT1 acts as miR-216b-5p sponge to attenuate its binding ability to ZNF146 and induce upregulation of ZNF146 expression in colorectal cancer cells [25]. This evidence concerns the gene KCNQ1OT1 and colorectal cancer.