ACO2 and ovarian cancer: In addition, miR-450a is the most significantly downregulated miRNAs in ovarian cancer, which restricts the metastatic capacity of ovarian cancer cells via targeting several mitochondrial mRNAs, such as translocase of inner mitochondrial membrane domain-containing protein 1 (TIMMDC1), aconitase 2 (ACO2), and ATP synthase F1 β subunit (ATP5B) [49].