Moreover, the study of three nDNA pathways demonstrates that 25 genes and 1051 SNPs involved in mitochondrial biogenesis are associated with ovarian cancer risk, including Nrf1 (nuclear respiratory factor 1), MTERF (mitochondrial transcription termination factor), PPARGC1A (peroxisome proliferator-activated receptor gamma, coactivator 1 alpha), CAMK2D (calcium/calmodulin-dependent protein kinase D), and ESRRA (estrogen-related receptor alpha) [38]. This evidence concerns the gene NRF1 and ovarian cancer.