However, the above effects and the inhibitory effect on IL-18 and IL-1β of MaR1 were attenuated by siRNA knockdown of LGR6 in HK-2 cells (Figure 6), suggesting MaR1 alleviates DKD via LGR6-mediated cAMP-SOD2 antioxidant pathway. The gene discussed is SOD2; the disease is diabetic kidney disease.