Moreover, Notch signaling pathway, hedgehog interacting protein, dipeptidyl peptidase-4 (DPP-4), decreasing sirtuin3 (SIRT3) and endothelial Fibroblast Growth Factor Receptor 1 (FGFR1) deficiency also result in renal fibrogenesis in DKD [9–13]. The gene discussed is SIRT3; the disease is diabetic kidney disease.