Similarly, miR-320 and miR-144-3p, have been shown to be involved in post-MI responses by regulating PTEN/PI3K/Akt signaling pathway (13, 84, 85); miR-144-3p promotes cardiac fibrosis via targeting PTEN following MI (14); miR-199a-3p and miR-590-3p also improve cardiac function after MI (8, 86); miR-19a/19b inhibits the inflammatory response and has been shown to enhance cardiac function post-MI by targeting Bim1 and PTEN (8). The gene discussed is PTEN; the disease is myocardial infarction.