Another miR fundamental in post-MI remodeling is miR-22: its overexpression triggers the synthesis of proinflammatory cytokines such as IL-1β, IL-6, and IL-8 (74), moreover, the same miR-22 is able to regulate inflammation and angiogenesis by specifically targeting VE-cadherin (10). This evidence concerns the gene IL1B and myocardial infarction.