For instance, reduced atherosclerosis along with increased B-1a cell numbers and circulating IgM levels were reported in atherosclerosis-prone mice that were deficient in sialic acid-binding immunoglobulin-like lectin G (72) or had been treated with an antibody against the phosphatidylserine receptor T-cell immunoglobulin and mucin domain-1 (73). This evidence concerns the gene JMJD6 and atherosclerosis.