Among these proteins, the Bcl-2 protein level decreased and the Bax protein level increased obviously in the combined treatment group, indicating that overexpression of Rab23 and LCA can also promote the apoptosis of glioma U251 cells by regulating the expression levels of Bcl-2 and Bax protein, thus playing an antitumor effect. This evidence concerns the gene RAB23 and central nervous system cancer.