TNF and intervertebral disk degenerative disorder: The results indicated that quercetin (Mol000098), luteolin (Mol000006), and kaempferol (Mol000422) were the main bioactive components, which may alleviate the occurrence and development of IDD through the AGE-RAGE signaling pathway in diabetic complications, TNF signaling pathway, IL-17 signaling pathway, cellular senescence, apoptosis, and PI3K-Akt signaling pathway.