Fibrosis in donors pretreated with S-NO-HSA and prolonged (12 h) ischemia was not significantly different to the reference group transplanted after 1 h of ischemia at 60 days after transplantation (6.47% ± 1.76 vs. 6.66% ± 2.72; p = 0.99; 12 h-S-NO-HSA-hHTX vs. 1 h-control-hHTX). This evidence concerns the gene ALB and fibrosis.