During recent investigations, it has been shown that PLAC8 plays a vital role in the death of human lymphocytes as well as autophagy, adipose differentiation, pneumonia, and, most significantly, cancer [16–21].PLAC8 overexpression suppresses the development of liver cancer cells [22] but enhances colon cancer cell invasion and epithelial-mesenchymal transition in recognized PLAC8-related malignancies [23].Furthermore, PLAC8 overexpression is strongly associated with poor outcomes in patients with pancreatic, prostate, and renal cancer [24–28]. This evidence concerns the gene PLAC8 and liver cancer.