Previous evidence unveiled that miR-22 was downregulated in CRC and the up-regulation of miR-22 could hinder proliferation, metastasis, and epithelial-mesenchymal transition (EMT) [26] Meanwhile, EMT score reflecting the possibility of metastasis was positively correlated with PD-L1 expression in tumors [34]. Here, CD274 is linked to colorectal carcinoma.