APOL1 and chronic kidney disease: Previous studies in adult populations of African Americans, Nigerians, and South Africans with HIV have also reported associations between APOL1 high-risk genotypes and FSGS,22 albuminuria,23,24 proteinuria, decline in eGFR,25 eGFR <60 ml/min per 1.73 m2,26 and CKD,27 and raised the possibility that individuals with a single APOL1 variant may be at increased risk of developing kidney disease17,26 and that the G1 variant may pose greater renal risk than the G2 variant.12