The main kidney pathologies associated with APOL1 variants, especially in those with APOL1 high-risk genotypes (G1/G1, G1/G2, G2/G2), are focal and segmental glomerulosclerosis (FSGS),12 focal global glomerulosclerosis (or solidified glomerulosclerosis), and collapsing glomerulopathy, particularly in those who have received interferon therapy,13 and more recently, in association with SARS-CoV-2 infection.14, 15, 16. Here, APOL1 is linked to focal segmental glomerulosclerosis.