After photoablation, Al-BSA - Ce6 NPs triggered a systemic anti-tumor immune response that T cells gathered in lymph nodes and infiltrated the tumor sites, increasing the levels of serum antibodies and cytokines, and the proportion of IFN-γ+ CD8+ T cells, TNF- α+ CD8+ T cells and IFN- γ+ CD4+ Th1 cells. Here, CD4 is linked to neoplasm.