Furthermore, AT-MSC-derived EVs overexpressing miR-15a, which targets the demethylase KDM4 that is deregulated in colorectal cancer cells, were shown to diminish the immune evasion of tumor cells via the KDM4B/HOXC4/PD-L1 axis, both in vitro and in vivo (Liu L. et al., 2021). This evidence concerns the gene CD274 and neoplasm.