TNFSF10 and neoplasm: For instance, human adult MSCs can be modified to deliver pro-apoptotic proteins or cytokines, such as tumor necrosis factor related apoptosis induced ligand (TRAIL), with positive anti-tumoral effects on colorectal cancer, or IL-12 overexpressing murine BM-MSCs that induced tumor cells apoptosis in melanoma and lung cancer murine models (Chulpanova et al., 2018).