We identified 18 genes that were related to ESCC patient prognosis, 11 of which were related to good prognosis (RELB, HNRNPL, ITCH, ILF3, PSMC4, CBL, SKP2, DHX33, PRKDC, ZMYND11, and CCDC88A) and seven that were related to poor prognosis (PSME2, PSMD6, GBP2, RABEP2, ZC3HAV1, GRN, and STC2) (Figures 3D, 4A–R). Here, ITCH is linked to esophageal squamous cell carcinoma.