We identified 18 genes that were related to ESCC patient prognosis, 11 of which were related to good prognosis (RELB, HNRNPL, ITCH, ILF3, PSMC4, CBL, SKP2, DHX33, PRKDC, ZMYND11, and CCDC88A) and seven that were related to poor prognosis (PSME2, PSMD6, GBP2, RABEP2, ZC3HAV1, GRN, and STC2) (Figures 3D, 4A–R). The gene discussed is SKP2; the disease is esophageal squamous cell carcinoma.